"Shutter Island" is Martin Scorsese's first film since winning an Oscar for helming best picture champ "The Departed" in 2006. This period crime drama -- due out Oct. 2 -- is based on the 2003 best-selling mystery by Dennis Lehane ("Mystic River"). Three-time Oscar nominee Leonardo DiCaprio ("What's Eating Gilbert Grape," "The Aviator," "Blood Diamond") takes direction from Scorsese for the fourth time.

The trailer below for "Shutter Island" suggests that Scorsese is operating in full Hitchcock mode. DiCaprio plays a U.S. marshal searching for a patient (Emily Mortimer) missing from a Massachusetts hospital for the criminally insane in 1954. Oscar winner Ben Kingsley ("Gandhi") is the head of the hospital with Oscar nominees Max Von Sydow ("Pelle the Conqueror") as a dubious doctor and Michelle Williams ("Brokeback Mountain") as DiCaprio's wife. 

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